David Siegel Selected Research

quinone (benzoquinone)

10/2016	Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation.
12/2015	A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity.
4/2013	Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.
4/2012	NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones.
5/2011	Mechanism-based inhibition of quinone reductase 2 (NQO2): selectivity for NQO2 over NQO1 and structural basis for flavoprotein inhibition.
5/2011	A mechanistic and structural analysis of the inhibition of the 90-kDa heat shock protein by the benzoquinone and hydroquinone ansamycins.
3/2011	Role for NAD(P)H:quinone oxidoreductase 1 and manganese-dependent superoxide dismutase in 17-(allylamino)-17-demethoxygeldanamycin-induced heat shock protein 90 inhibition in pancreatic cancer cells.
7/2010	NAD(P)H:quinone oxidoreductase 1-compromised human bone marrow endothelial cells exhibit decreased adhesion molecule expression and CD34+ hematopoietic cell adhesion.
11/2009	Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1).
12/2007	Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity.

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David Siegel Research Topics

Disease

54	Multiple Myeloma 01/2022 - 03/2002
22	Neoplasms (Cancer) 09/2021 - 03/2002
12	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2021 - 11/2007
9	Hypertension (High Blood Pressure) 01/2019 - 12/2004
8	Pancreatic Neoplasms (Pancreatic Cancer) 07/2014 - 07/2006
7	Leukemia 01/2016 - 08/2004
6	Breast Neoplasms (Breast Cancer) 01/2020 - 11/2005
6	Inflammation (Inflammations) 10/2016 - 08/2008
5	Insulin Resistance 11/2020 - 09/2007
4	Fatigue 06/2020 - 03/2008
4	Hematologic Neoplasms (Hematological Malignancy) 01/2020 - 07/2009
4	Diabetes Mellitus 01/2019 - 06/2003
3	Diarrhea 01/2020 - 03/2008
3	Nausea 01/2020 - 03/2008
3	Chronic Obstructive Pulmonary Disease (COPD) 01/2017 - 11/2012
3	Obesity 01/2017 - 09/2015
3	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2015 - 04/2013
3	Carcinoma (Carcinomatosis) 11/2003 - 03/2003
2	Non-Hodgkin Lymphoma (Lymphosarcoma) 11/2020 - 01/2020
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 11/2020 - 01/2020
2	Neutropenia 01/2020 - 11/2007
2	Thrombocytopenia (Thrombopenia) 01/2020 - 07/2009
2	Glioblastoma (Glioblastoma Multiforme) 01/2020 - 07/2009
2	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2020 - 06/2010
2	Vomiting 01/2020 - 07/2009
2	Waldenstrom Macroglobulinemia (Macroglobulinemia) 01/2019 - 01/2018
2	Lymphoma (Lymphomas) 01/2016 - 12/2008
2	Heart Failure 11/2013 - 06/2003
2	Atherosclerosis 04/2013 - 02/2011
2	Aneurysm (Aneurysms) 12/2012 - 05/2011
2	Type 2 Diabetes Mellitus (MODY) 04/2011 - 06/2002
2	Disease Progression 02/2011 - 07/2009
2	Anorexia 07/2009 - 03/2008
2	Dehydration (Water Stress) 07/2009 - 03/2008
2	Chromosome Aberrations (Chromosome Abnormalities) 10/2006 - 05/2003
1	Cholelithiasis 04/2021
1	Alzheimer Disease (Alzheimer's Disease) 01/2021
1	COVID-19 01/2021

Drug/Important Bio-Agent (IBA)

16	Dexamethasone (Maxidex)FDA LinkGeneric 01/2022 - 03/2002
15	carfilzomibIBA 01/2022 - 06/2011
15	quinone (benzoquinone)IBA 10/2016 - 05/2003
13	Proteins (Proteins, Gene)FDA Link 11/2020 - 03/2003
10	Lenalidomide (CC 5013)FDA Link 01/2022 - 10/2007
10	Oxidoreductases (Dehydrogenase)IBA 10/2016 - 05/2003
10	NAD (NADH)IBA 10/2016 - 05/2003
8	Pharmaceutical PreparationsIBA 01/2021 - 12/2004
7	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 06/2002
7	C-Reactive ProteinIBA 01/2019 - 10/2006
6	selinexorIBA 09/2021 - 01/2018
6	Biomarkers (Surrogate Marker)IBA 01/2021 - 08/2008
6	Bortezomib (Velcade)FDA Link 01/2020 - 06/2003
6	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2019 - 11/2007
6	EnzymesIBA 01/2017 - 07/2006
5	tanespimycin (17AAG)IBA 12/2015 - 11/2005
5	IndolequinonesIBA 07/2014 - 05/2007
4	daratumumabIBA 01/2022 - 01/2020
4	Insulin (Novolin)FDA Link 01/2021 - 02/2012
4	Dicumarol (Dicoumarol)FDA Link 01/2012 - 07/2006
4	Antihypertensive Agents (Antihypertensives)IBA 07/2011 - 01/2007
4	Benzene (Benzole)IBA 06/2011 - 08/2004
3	B-Cell Maturation AntigenIBA 01/2021 - 01/2019
3	LipidsIBA 11/2020 - 08/2008
3	Messenger RNA (mRNA)IBA 01/2020 - 10/2016
3	Proteasome InhibitorsIBA 01/2017 - 11/2013
3	Rifabutin (Ansamycin)FDA Link 12/2015 - 04/2012
3	Thalidomide (Thalomid)FDA Link 01/2014 - 11/2007
3	Heat-Shock Proteins (Heat-Shock Protein)IBA 04/2013 - 03/2011
3	Antineoplastic Agents (Antineoplastics)IBA 04/2012 - 07/2009
3	NRH - quinone oxidoreductase2IBA 08/2011 - 12/2008
3	Blood Glucose (Blood Sugar)IBA 04/2011 - 06/2002
3	Superoxides (Superoxide)IBA 08/2008 - 07/2006
2	idecabtagene vicleucelIBA 01/2021 - 01/2019
2	Chimeric Antigen ReceptorsIBA 01/2021 - 01/2019
2	bis(3- bis(4- chlorophenyl)methyl- 4- dimethylaminophenyl)amineIBA 01/2020 - 01/2019
2	Exportin 1 ProteinIBA 01/2020 - 01/2018
2	Simvastatin (Zocor)FDA LinkGeneric 01/2019 - 11/2007
2	LDL CholesterolIBA 08/2017 - 08/2008
2	oxidized low density lipoproteinIBA 08/2017 - 08/2008
2	pomalidomideIBA 06/2017 - 03/2013
2	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 01/2017 - 10/2016
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2016 - 07/2013
2	geldanamycinIBA 12/2015 - 04/2013
2	AdiponectinIBA 12/2014 - 11/2007
2	Histone Deacetylase InhibitorsIBA 01/2014 - 07/2009
2	PanobinostatIBA 10/2013 - 09/2012
2	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 03/2012 - 06/2003
2	Thioredoxin-Disulfide ReductaseIBA 03/2012 - 07/2009
2	Angiotensin Receptor AntagonistsIBA 03/2012 - 06/2003
2	PotassiumIBA 07/2011 - 04/2008
2	Macrocyclic LactamsIBA 05/2011 - 10/2006
2	LDL Lipoproteins (beta Lipoproteins)IBA 02/2011 - 08/2008
2	Vorinostat FDA Link 07/2009 - 03/2008
2	indoleIBA 07/2009 - 07/2006
1	PENTAIBA 09/2021
1	BilirubinIBA 04/2021
1	Therapeutic UsesIBA 01/2021

Therapy/Procedure

23	Therapeutics 01/2022 - 03/2002
4	Drug Therapy (Chemotherapy) 01/2019 - 03/2002
3	Immunotherapy 01/2019 - 11/2013
2	Duration of Therapy 01/2019 - 02/2011